![]() Their entry coincides with decline in neutrophil infiltration. īlood monocytes begin infiltrating the wound within 2 days of injury. Also, the proinflammatory cytokines secreted by neutrophils facilitate recruitment of fibroblasts and epithelial cells at the site of injury these cells are involved in repair and remodeling of the damaged tissue. Additionally, neutrophils release reactive oxygen species (ROSs) which possess anti-infective properties. Proteases also facilitate migration of neutrophils into the extracellular space where they prevent contamination and infection from local bacterial flora by performing phagocytosis. ![]() They secrete proteases, including elastase, which degrade and remove cellular debris and hence help in the cleaning up process α-1 protease inhibitor secreted by macrophages regulates the activity of elastase. Neutrophils are the first leukocytes to reach the injury site where they attach to the vascular endothelial cells and subsequently pass out to the extravascular space. It begins with the release of growth factors and inflammatory cytokines from the activated platelets and the damaged cells, which attract inflammatory cells from circulation-the leukocytes-to the site of injury. Inflammation starts within 24 h of the injury and lasts for 2 weeks or more. This article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors. This paper revisits the role and clinical utility of trypsin:chymotrypsin combination in tissue repair. It provides better resolution of inflammatory symptoms and promotes speedier recovery of acute tissue injury than several of the other existing enzyme preparations. Trypsin:chymotrypsin is an oral proteolytic enzyme preparation which has been in clinical use since the 1960s. ![]() Proteolytic enzymes have been used to facilitate tissue repair since ancient times. Hence, prompt and effective management of acute tissue injury is necessary to prevent it from progressing to a chronic wound. They also incur substantial healthcare-related financial burden. Chronic wounds thus formed are a source of significant morbidity, mortality, and poor quality of life. Impaired tissue repair is a common medical problem, affecting millions of people worldwide. This review article revisits the role and clinical utility of trypsin:chymotrypsin combination in tissue repair.įunding: Torrent Pharmaceuticals Limited. ![]() Therefore, prompt and effective management of acute tissue injury is necessary to prevent it from progressing to a chronic wound. Chronic wounds are associated with significant morbidity, mortality, and poor quality of life. If the process is interrupted or halted during any stage, it leads to impaired healing and formation of a chronic wound. The tissue repair process can be broadly divided into four continuous and overlapping phases-hemostasis and coagulation, inflammation, proliferation, and remodeling. Tissue damage of all types, such as surgical or accidental injuries, fractures, and burns, stimulates a well-orchestrated, physiological process of healing, which ultimately leads to structural and functional restoration of the damaged tissues.
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